2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. PF-4178903

PF-4178903  (Synonyms: INCB10820)

目录号: HY-119658
产品使用指南

摩尔计算器

PF-4178903 (INCB10820) 是一种具有口服活性的双 CCR2 和 CCR5 拮抗剂，IC50 值分别为 3 nM 和 5.3 nM。PF-4178903 有望用于慢性炎症和自身免疫性疾病的研究。

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PF-4178903 Chemical Structure

PF-4178903 Chemical Structure

CAS No. : 1310796-72-5

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PF-4178903 相关抗体

Top Publications Citing Use of Products

查看 CCR 亚型特异性产品:

查看所有亚型
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-4178903 (INCB10820) is an orally active, potent dual CCR2 and CCR5 antagonist with IC50 values of 3 nM and 5.3 nM, respectively. PF-4178903 is promising for research of chronic inflammatory and autoimmune diseases[1].

IC50 & Target

CCR2

3 nM (IC50)

CCR5

5.3 nM (IC50)

分子量

498.58

Formula

C25H37F3N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PF-4178903 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-41789031310796-72-5INCB10820PF4178903PF 4178903INCB 10820INCB-10820CCRCC chemokine receptororally activeCCR2CCR5chronic inflammatoryautoimmune diseasesInhibitorinhibitorinhibit

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