2. Apoptosis
  3. Photosensitizer
  4. Photosensitizer-2

Photosensitizer-2 (化合物 1) 是一种具有光毒性的有机 D-π-A 光敏剂 (D-π-A sensitizer)。Photosensitizer-2 含有丙烯酸部分，表现出高水平的光毒性。Photosensitizer-2 对 HeLa 细胞具有抗肿瘤活性，其 IC50 值分别为 20.9 ± 4.5 μM (暗) 和 0.046 ± 0.012 μM (照射)。

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Photosensitizer-2 Chemical Structure

Photosensitizer-2 Chemical Structure

CAS No. : 2138330-43-3

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Photosensitizer-2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Photosensitizer-2 (compound 1) is a organic D-π-A sensitizer against phototoxicity. Photosensitizer-2 contains an acrylic acid moiety that exerts high levels of phototoxicity. Photosensitizer-2 shows antitumor activity against HeLa cells, with IC50 values of 20.9 ± 4.5 μM (dark) and 0.046 ± 0.012 μM (irradiation), respectively[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
0.046 μM
Compound: 1
Phototoxicity against human HeLa cells assessed as reduction in cell viability preincubated for 1 hr followed by white LED irradiation for 15 mins and measured after 48 hrs by MTT assay
Phototoxicity against human HeLa cells assessed as reduction in cell viability preincubated for 1 hr followed by white LED irradiation for 15 mins and measured after 48 hrs by MTT assay
[PMID: 32546300]
HeLa IC50
13.8 μM
Compound: 1
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs measured under dark conditions by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs measured under dark conditions by MTT assay
[PMID: 32546300]
分子量

479.61

Formula

C29H21NO2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Photosensitizer-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Photosensitizer-22138330-43-3Photosensitizer2Photosensitizer 2PhotosensitizerHeLa cellsantitumor activityphotodynamic therapyPDTorganic dyesensitizersinglet oxygenendocytosisphototoxicityInhibitorinhibitorinhibit

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