Phytic acid sodium salt  (Synonyms: 植酸钠; myo-Inositol, hexakis(dihydrogen phosphate) sodium salt; Inositol hexaphosphate sodium salt)

Phytic acid sodium salt (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound derived from the seeds of legumes. Phytic acid sodium salt is a [PO4]³- storage depot and precursor for other inositol phosphates and pyrophosphates. phytic acid is hydrolyzed by phytases in a stepwise manner in the plant. Phytic acid sodium salt attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid sodium salt can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research^{[1][2][3][4][5][6][7][8][9][10]}.

IC50: precursor for inositol phosphates and pyrophosphates^[1]

Phytic acid (0.05%-0.4% (wt/wt)，5 min) sodium salt 和氯化钠对未适应和酸适应的大肠杆菌 O157:H7 菌株表现出明显的协同杀菌作用^[2]。
Phytic acid (1-5 mM, 2-3 h) sodium salt 通过调节 TJ 蛋白的定位和下调 TJ 蛋白的表达水平来降低 Caco-2 细胞单层的完整性，并且不会对 Caco-2 细胞造成细胞毒性^[3]。
Phytic acid (48-72 h) sodium salt 通过减弱 MC65 细胞中钙、过氧化氢、超氧化物、Aβ 寡聚体的水平，提供对淀粉样蛋白前体-C 末端片段诱导的细胞毒性的完全保护，并适度上调自噬蛋白的表达 (beclin-1)^[5]。
Phytic acid (≥1 mM) sodium salt 刺激自杀性人类红细胞死亡^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Phytic acid (2%，随意饮食，21 天) sodium salt 降低猪的生长性能，部分原因是小肠吸收 Na 的能力降低^[4]。
Phytic acid (2%，饮用水，6 个月) sodium salt 改善 Tg2576 小鼠的阿尔茨海默病病理 (AP180、beclin-1、LC3B、sirtuin 1)^[5]。
Phytic acid (20 mg/kg，腹腔注射，冠状动脉闭塞前 5 h 预处理) sodium salt 抑制大鼠心肌缺血诱导的羟基自由基生成^[7]。
Phytic acid (100 mg/kg/d，灌胃，每周 5 天，8 周) sodium salt 对 CCl₄ 诱导的肝损伤具有保护作用小鼠纤维化^[8]。
Phytic acid (啮齿动物饲料的 4%，饮食，30 天) sodium salt 可降低糖尿病大鼠的脂肪生成酶活性^[9]。
Phytic acid (1-2 g/100 g，在水中，13 周) sodium salt 在结肠癌大鼠中表现出抗致癌作用，ACF 分别减少 36% (1 g/100 g Phytic acid) 和 42% (2 g/100 g Phytic acid)^[10]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C₆H₁₈O₂₄P₆.xNa

14306-25-3

固体

White to off-white

植酸钠；肌醇六磷酸钠

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Shears SB, et al.Assessing the omnipotence of inositol hexakisphosphate.Cell Signal. 2001 Mar;13(3):151-8.  [Content Brief]

  [2]. Kim NH, et al. Phytic Acid and Sodium Chloride Show Marked Synergistic Bactericidal Effects against Nonadapted and Acid-Adapted Escherichia coli O157:H7 Strains. Appl Environ Microbiol. 2015 Dec 4;82(4):1040-1049.  [Content Brief]

  [3]. Fu Q, et al. The effect of phytic acid on tight junctions in the human intestinal Caco-2 cell line and its mechanism. Eur J Pharm Sci. 2015 Dec 1;80:1-8.  [Content Brief]

  [4]. Woyengo TA, et al. Effect of dietary phytic acid on performance and nutrient uptake in the small intestine of piglets. J Anim Sci. 2012 Feb;90(2):543-9.  [Content Brief]

  [5]. Anekonda TS, et al. Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models. J Alzheimers Dis. 2011;23(1):21-35.  [Content Brief]

  [6]. Eberhard M, et al. Effect of phytic acid on suicidal erythrocyte death. J Agric Food Chem. 2010 Feb 10;58(3):2028-33.  [Content Brief]

  [7]. Obata T, et al. Phytic acid suppresses ischemia-induced hydroxyl radical generation in rat myocardium. Eur J Pharmacol. 2016 Mar 5;774:20-4.  [Content Brief]

  [8]. Xu Z, et al. Protective effects of phytic acid on CCl4‐induced liver fibrosis in mice. Journal of Food Biochemistry, 2023, 2023(1): 6634450.

  [9]. Omoruyi FO, et al. The potential benefits and adverse effects of phytic Acid supplement in streptozotocin-induced diabetic rats. Adv Pharmacol Sci. 2013;2013:172494.  [Content Brief]

  [10]. Verghese M, et al. Anticarcinogenic effect of phytic acid (IP6): apoptosis as a possible mechanism of action. LWT-Food Science and Technology, 2006, 39(10): 1093-1098.