2. Anti-infection PI3K/Akt/mTOR Epigenetics
  3. Bacterial AMPK
  4. Pinocembrin chalcone

Pinocembrin chalcone  (Synonyms: 2',4',6'-Trihydroxychalcone)

目录号: HY-N7515 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) 是一种来自蜡菊 (Helichrysum Trilineatum) 的抗菌 (antibacterial) 化合物。Pinocembrin chalcone 促进 AMP 激活的蛋白激酶 (AMPK) 活化，改善葡萄糖耐受性，增加肌肉脂肪酸氧化 (FAO)，并在高脂饮食诱导的糖尿病小鼠中减少肝脏和骨骼肌中的脂肪积累。Pinocembrin chalcone 有望用于胃溃疡和糖尿病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pinocembrin chalcone Chemical Structure

Pinocembrin chalcone Chemical Structure

CAS No. : 4197-97-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2500
In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

Pinocembrin chalcone 相关抗体

Top Publications Citing Use of Products

查看 AMPK 亚型特异性产品:

查看所有亚型
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
25.4 μM
Compound: 8c
Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
[PMID: 28098449]
HEK293 IC50
33.3 μM
Compound: 8c
Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose addition in presence of sodium buffer measured after 1 hr by resazurin dye based fluorescence assay
[PMID: 28098449]
体外研究
(In Vitro)

Pinocembrin chalcone (1.0 μg) 能有效抑制金黄色葡萄球菌 (S. aureus.) 的生长[1]。
Pinocembrin chalcone (10 μM, 24 小时) 显著提高了 C2C12 肌管的脂肪酸氧化速率，并增加了 AMPKα 的磷酸化，没有细胞毒性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pinocembrin chalcone 相关抗体:

Western Blot Analysis[2]

Cell Line: C2C12 myotubes
Concentration: 10 μM
Incubation Time: 24 h
Result: Stimulated AMPK phosphorylation at much lower concentrations (1 μM) within 2 h in C2C12 myotubes.
体内研究
(In Vivo)

Pinocembrin chalcone (30 mg/kg, 口服强饲, 每天口服，持续 3 周) 通过提高高脂饮食诱导的糖尿病小鼠中骨骼肌的脂肪酸氧化率来改善葡萄糖耐受性和脂肪积累，这主要是通过激活 AMPK 实现的[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-induced diabetic mice[2]
Dosage: 30 mg/kg
Administration: oral gavage, daily for 3 weeks
Result: Reduced the circulating FFA levels and fat accumulation in the liver and muscles by increasing FAO, which improved glucose tolerance in HFD-induced diabetic mice.
分子量

256.25

Formula

C15H12O4
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

2',4',6'-三羟基查耳酮
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: ≥98.0%

COA (262 KB)

产品使用指南 (1538 KB)
参考文献

Pinocembrin chalcone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pinocembrin chalcone4197-97-12',4',6'-Trihydroxychalcone2',4',6'-三羟基查耳酮BacterialAMPKAMP-activated protein kinaseantibacterial compoundglucose toleranceFAOfat accumulationhigh-fat diet-induced diabetic micegastric ulcersdiabetesInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Pinocembrin chalcone
目录号：
HY-N7515
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z