2. Metabolic Enzyme/Protease
  3. Dihydrofolate reductase (DHFR)
  4. Piritrexim

Piritrexim  (Synonyms: 吡曲克辛; BW 301U; NSC 351521)

目录号: HY-106434
产品使用指南

摩尔计算器

Piritrexim (BW 301U) 是一种有效的二氢叶酸还原酶 dihydrofolate reductase (DHFR) 抑制剂，可抑制 Pneumocystis carinii 和 Toxoplasma gondii，其对 PcDHFR 和 TgDHFR 的 IC50 值分别为 0.038 和 0.011 μM。Piritrexim 可用于获得性免疫缺陷综合征 (AIDS) 研究。Piritrexim 也是一种抗癌剂。

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Piritrexim Chemical Structure

Piritrexim Chemical Structure

CAS No. : 72732-56-0

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规格 价格 是否有货
1 mg ￥4200
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Piritrexim 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Piritrexim (BW 301U) is a potent dihydrofolate reductase (DHFR) inhibitor against Pneumocystis carinii and Toxoplasma gondii, with IC50 values of 0.038 and 0.011 μM, respectively. Piritrexim can be used for acquired immune deficiency syndrome (AIDS) research. Piritrexim also is an anticancer agent[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM IC50
0.013 μM
Compound: 5
Concentration causing inhibition of CCRF-CEM human leukemic lymphoblasts growth in a 72 hr culture
Concentration causing inhibition of CCRF-CEM human leukemic lymphoblasts growth in a 72 hr culture
[PMID: 15974594]
分子量

325.37

Formula

C17H19N5O2
CAS 号
中文名称

吡曲克辛
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Piritrexim 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Piritrexim72732-56-0BW 301U NSC 351521吡曲克辛NSC351521NSC 351521NSC-351521Dihydrofolate reductase (DHFR)Pneumocystis cariniiToxoplasma gondiiAIDSanticancerInhibitorinhibitorinhibit

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