2. Neuronal Signaling
  3. Amyloid-β
  4. Pittsburgh Compound B

Pittsburgh Compound B  (Synonyms: PiB; 6-OH-BTA-1)

目录号: HY-126192
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Pittsburgh Compound B (PiB) 是一种阿尔茨海默病 (AD) Aβ 沉积的 PET 示踪剂，具有高亲和力和特异性。通过点击化学修饰 (在 Pittsburgh Compound B 的 6-羟基位点引入 PEG3 连接臂和炔基来制备可点击 Pittsburgh Compound B 衍生物，并利用铜催化叠氮-炔基环加成反应 (CuAAC) 与叠氮标记的荧光染料或亲和标签进行共价偶联)，Pittsburgh Compound B 及其共轭物可用于荧光成像、超微结构研究及 Aβ 复合物的富集和表征。Pittsburgh Compound B 在阿尔茨海默病研究中的应用潜力。

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Pittsburgh Compound B Chemical Structure

Pittsburgh Compound B Chemical Structure

CAS No. : 566169-93-5

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Pittsburgh Compound B 相关抗体

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  • 生物活性

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生物活性

Pittsburgh Compound B (PiB) is a PET tracer for Aβ deposition in Alzheimer's disease (AD), with high affinity and specificity. Through click chemistry modification (introducing a PEG3 linker and an alkyne group at the 6-hydroxy position of Pittsburgh Compound B to generate a clickable Pittsburgh Compound B derivative, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and the enrichment and characterization of Aβ complexes. Pittsburgh Compound B holds great potential in Alzheimer's disease research[1].

分子量

256.33

Formula

C14H12N2OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pittsburgh Compound B 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Pittsburgh Compound B566169-93-5PiB 6-OH-BTA-1Amyloid-ββ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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