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  4. PLGA (75:25)

PLGA (75:25)  (Synonyms: 乳酸/乙醇酸共聚物 (75:25); poly(lactic-co-glycolic acid) (75:25))

目录号: HY-B2247A 含量: 99.54%
COA 产品使用指南

摩尔计算器

PLGA (75:25) 是一种低毒的，具有生物相容性和生物降解性的活性分子控释载体，可在生物体内达到缓释的作用。PLGA (75:25) 由 75% 聚乳酸 (PLA) 和 25% 聚乙醇酸 (PGA) 的聚合而成。PLGA (75:25) 已被广泛用于活性分子、蛋白质和其他各种大分子如 DNA、RNA和肽的输送研究。

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PLGA (75:25) Chemical Structure

PLGA (75:25) Chemical Structure

CAS No. : 34346-01-5

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规格 价格 是否有货 数量
100 mg ￥500
In-stock
500 mg ￥1500
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Customer Review

Other Forms of PLGA (75:25):

PLGA (75:25) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides[1][2][3].

体外研究
(In Vitro)

PLGA 75:25 (0.03-5 mg/mL；72 小时) 仅在浓度过高而无法用于临床时影响 Calu-3 细胞的活力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PLGA (75:25) 相关抗体:

Cell Viability Assay[1]

Cell Line: Calu-3 cells
Concentration: 0.03-5 mg/mL (for PLgA (75:25)/PVA and PLgA (75:25)/CS); 3-5 mg/mL (for PLgA (75:25)/CS and PLgA (75:25)/PF68); 0.03-1 mg/mL (for PLgA (75:25)/PVA and PLgA (75:25)/PF68) (CS (chitosan), PF68 and PVA (poly vinyl alcohol) serve as cationic stabilizer)
Incubation Time: 72 h
Result: Showed low toxicity to cells (cell viability was always higher than 50%) even at the highest concentration tested, when xposured to PLgA (75:25)/PVA, PLgA (75:25)/CS and PLgA (75:25)/PF68 nanoparticles.
Increased cell viability, after short exposure (4 hours) to PLGA/PF68 nanoparticles.
体内研究
(In Vivo)

PLGA 75:25 (40 mg/kg Risperidone (PLGA 75:25 as a drug delivery carrier)；sc；single) 具有良好的45天缓释活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[2].
Dosage: 40 mg/kg (dose of Risperidone, PLGA (75:25) as a drug delivery carrier).
Administration: Subcutaneous injection; single.
Result: Achieved slow release in vivo: after an initial burst, a sharp drop occurred and the drug levels through day 22 remained in a steady manner while progressing to a decline up to day 45.
CAS 号
性状

固体

颜色

White to off-white

中文名称

乳酸/乙醇酸共聚物 (75:25)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.54%

COA (257 KB)

产品使用指南 (1538 KB)
参考文献

PLGA (75:25) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PLGA (75:25)34346-01-5poly(lactic-co-glycolic acid) (75:25)乳酸/乙醇酸共聚物 (75:25)Biochemical Assay ReagentsPGAPLAPLGAslow-release drugsdrug delivery carrierpolymeric nano-compositesCalu-3Inhibitorinhibitorinhibit

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