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  5. Polygalacturonic acid

Polygalacturonic acid  (Synonyms: Galacturonic acid polymer)

目录号: HY-N6613 含量: 95.16%
COA 产品使用指南

Polygalacturonic acid (Galacturonic acid polymer) 是透明胶状酸,是细胞壁的主要成分。Polygalacturonic acid 可用于制备银纳米颗粒 (AgNPs),作为抗氧化剂和抗炎剂,保护细胞免受 ROS 升高的破坏作用,并加速伤口愈合。Polygalacturonic acid 纳米颗粒也表现出抗菌活性。

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Polygalacturonic acid Chemical Structure

Polygalacturonic acid Chemical Structure

CAS No. : 25990-10-7

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity[1][2].

体外研究
(In Vitro)

Polygalacturonic acid can be used to format a durable hydrogel, to prolong the effect of drugs. Polygalacturonic acid hydrogel/hyaluronate, conjugated Ibuprofen (HY-78131) for example, prevents epidural fibrosis, the severe scar tissue adhesion of laminectomized male adult rats, and increases the efficiency of local inflammation control and reduces the side-effect of Ibuprofen[1].
Polygalacturonic acid hydrogel/hyaluronate (PGA-HA) (2%, 200 μL; 24 h) shows low cytotoxicity on L929 fibroblasts[1].
Polygalacturonic acid (PGA) preparing (Ag-PGA/HA)-PVA nanoparticles, shows anti-bacterial activity against gram-positive bacterial strains; Bacillus Subtilis and Staphylococcus Aureus, as well as gram-negative bacterial strain; Escherichia Coli[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Polygalacturonic acid (external application; 14 d) enhances a quick healing of wound infection in albino rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Full thickness wound model in albino rats (60-day-old, 180 g)[2]
Dosage: Ag-Polygalacturonic acid/hyaluronic acid nanoparticles
Administration: Applied on dorsal muscle fascia; cleaned the wound daily with alcohol; for 14 days
Result: Resulted no sign of abscess formation or hypertrophic scars both in the early phase; 5th day or in the final phase; 14th day, respectively.
Showed significant wound healing from day 8 while treated with (Ag-PGA/HA)-PVA nanofiber and blank (PGA/HA)-PVA nanofiber and induced epithelization on day 14.
Formula

(C6H10O7)x

CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

聚半乳糖醛酸; 半乳糖醛酸聚合物

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验: 

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 95.16%

参考文献
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Polygalacturonic acid
目录号:
HY-N6613
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