2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. PPAR agonist 5

PPAR agonist 5 (compound 4b) 是一种有效的 PPAR 激动剂，对 PPARα、PPARβ/δ、PPARγ 的 EC50 值分别为 3.20、1.51、1.92 µM。PPAR agonist 5 具有抗炎作用。

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PPAR agonist 5 Chemical Structure

PPAR agonist 5 Chemical Structure

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PPAR agonist 5 相关抗体

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查看 PPAR 亚型特异性产品:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PPAR agonist 5 (compound 4b) is a potent PPAR agonist with EC50 values of 3.20, 1.51, 1.92 µM for PPARα, PPARβ/δ, PPARγ, respectively. PPAR agonist 5 shows anti-inflammatory effect[1].

IC50 & Target[1]

PPARα

3.20 μM (EC50)

PPARβ/δ

1.51 μM (EC50)

PPARγ

1.92 μM (EC50)

体外研究
(In Vitro)

PPAR agonist 5 (compound 4b) (10 µM; 4, 24 h) 降低 LPS (HY-D1056) 诱导的 CCL-2 和 IL-6 mRNA 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PPAR agonist 5 相关抗体:

RT-PCR[1]

Cell Line: THP-1 human monocytes differentiated into macrophages
Concentration: 10 µM
Incubation Time: 4, 24 h
Result: Decreased the LPS (HY-D1056) (10 ng/mL)-induced expression of CCL-2 at 4 and 24 h and the expression of IL-6 at 24 h.
分子量

403.51

Formula

C26H29NO3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PPAR agonist 5 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPAR agonist 5PPAR agonist5PPAR agonist-5PPARPeroxisome proliferator-activated receptorsmacrophagesCCL-2IL-6anti-inflammatoryInhibitorinhibitorinhibit

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产品名称：
PPAR agonist 5
目录号：
HY-163547
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