2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Prostaglandin Receptor Endogenous Metabolite
  4. Prostaglandin J2

Prostaglandin J2  (Synonyms: 前列腺素J2; PGJ2)

目录号: HY-113366 纯度: 98.10%
COA 产品使用指南

摩尔计算器

Prostaglandin J2 (PGJ2) 是前列腺素 D2 (PGD2; HY-101988) 的一种内源性代谢物，是一种有效的 PGD2 受体 (DP) 激动剂，对 hDP 和 hCRTH2 的 Ki 分别为 0.9 nM 和 6.6 nM。Prostaglandin J2 刺激细胞内环 AMP 的产生，EC50 值为 1.2 nM。Prostaglandin J2 诱导氧化应激和神经细胞凋亡。Prostaglandin J2 诱导泛素化 (Ub) 蛋白的积累/聚集。Prostaglandin J2 具有高度神经毒性，可导致许多神经退行性疾病，包括阿尔茨海默病 (AD) 和帕金森病 (PD)。

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Prostaglandin J2 Chemical Structure

Prostaglandin J2 Chemical Structure

CAS No. : 60203-57-8

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规格 价格 是否有货 数量
500μg (14.95 mM * 100 μL in Methyl acetate) ￥1818
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Prostaglandin J2 相关抗体

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查看 Prostaglandin Receptor 亚型特异性产品:

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DP EP FP IP TXA2/TP TXB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD)[1][2][3][4].

IC50 & Target[1][2]

hDP

0.9 nM (Ki)

hCRTH2

6.6 nM (Ki)

hEP1

15.678 μM (Ki)

hEP2

989 nM (Ki)

hEP3

319 nM (Ki)

hEP4

1065 nM (Ki)

hFP

553 nM (Ki)

hIP

>25 μM (Ki)

hTP

6426 nM (Ki)

Human Endogenous Metabolite

 

体内研究
(In Vivo)

Prostaglandin J2 (PGJ2; 33.4 μg/注射; 单侧注射到 SNpc; 每周一次; 持续 2 或 4 周) 诱导大鼠进行性 PD 样病理，并表现出小胶质细胞和星形胶质细胞激活以及运动缺陷[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sixteen-week-old Sprague Dawley male rats[4]
Dosage: 33.4 μg/injection
Administration: Unilateral (right side) injections to the SNpc; once per week for 2 or 4 weeks
Result: Induced progressive dopaminergic neuronal loss in the rat substantia nigra pars compacta (SNpc).
Developed parkinsonian-like motor deficits in a progressive manner.
分子量

334.45

Formula

C20H30O4
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

前列腺素J2
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: 98.10%

COA (292 KB)

产品使用指南 (1538 KB)
参考文献

Prostaglandin J2 相关分类

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Keywords:

Prostaglandin J260203-57-8PGJ2前列腺素J2Prostaglandin J 2Prostaglandin J-2PGJ 2PGJ-2Prostaglandin ReceptorEndogenous Metaboliteendogenous metaboliteprostaglandin D2PGD2DPHdphCRTH2cyclic AMPoxidative stressneuronal apoptosisubiquitinatedneurodegenerativeAlzheimer'sADParkinson's diseasesPDInhibitorinhibitorinhibit

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