2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-17
  6. IL-17C

IL-17C  (白细胞介素-17C)

重组蛋白定制服务

Interleukin-17C (IL-17C) 属于 IL-17 细胞因子家族。IL-17C 主要由上皮细胞表达，由表达嗜铬粒蛋白 A (肠内分泌细胞) 和粘蛋白 (杯状细胞) 的细胞产生。IL-17C 也可在角质形成细胞、单核细胞和内皮细胞中表达。IL-17C 与其功能受体结合，受体是一种由 IL-17RA 和 IL-17RE 形成的异二聚体。TLR2、TLR3 和 TLR5 上调黏膜表面 IL-17C 的表达。IL-17C 的表达也受细胞因子 (TNF-α、IL-1β和IL-17A) 的调控。IL-17C 是抵御细菌病原体的早期反应的细胞因子，并上调多种抗菌肽的表达，包括人类 β-防御素 2 (hBD2)、脂钙素 2 (LCN2) 和颗粒酶 B。IL-17C 还刺激细胞因子 (IL-1β、TNF-α 和 IL-6) 的释放。IL-17C 与自身免疫性疾病和细菌感染有关[1]。人和小鼠 IL-17C 序列一致性为 76.68%。

Interleukin-17C (IL-17C) belongs to the IL-17 cytokine family. IL-17C is predominantly expressed by epithelial cells and is produced by cells expressing Chromogranin A (enteroendocrine cells) and mucin (goblet cells). IL-17C can also be expressed in keratinocytes, mononuclear cells, and endothelial cells. IL-17C binds to its functional receptor, a heterodimer formed by IL-17RA and IL-17RE. TLR2, TLR3, and TLR5 upregulate the expression of IL-17C at mucosal surfaces. The expression of IL-17C is also regulated by cytokines (TNF-α, IL-1β and IL-17A). IL-17C is an early response cytokine in the defense against bacterial pathogens and upregulates the expression of a variety of antimicrobial peptides including human beta-defensin 2 (hBD2), Lipocalin 2 (LCN2), and granzyme B. IL-17C also stimulates the release of cytokines (IL-1β, TNF-α, and IL-6). IL-17C is implicated in autoimmune disorders and bacterial infections[1]. Human and mouse IL-17C shares 76.68% sequence identity.

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