2. 重组蛋白
  3. Cytokines and Growth Factors CD Antigens
  4. Interleukin & Receptors Epithelial cell CD Proteins Endothelial cell CD Proteins
  5. IL-17 Receptor
  6. IL-17RA/CD217

IL-17RA/CD217  (白介素-17 受体 A)

重组蛋白定制服务

白细胞介素 17 受体 A (IL-17RA)，也称为 CD217，是一种与白细胞介素 17 结合的细胞因子受体。IL-17RA 是一种由活化的 T 淋巴细胞分泌的促炎细胞因子。IL-17受体家族由从 IL-17RA 到 IL-17RE 的五个成员组成。亚基 IL-17RA 无处不在，是 IL-17 家族其他成员的共同受体亚基。IL-17RA 基因定位于人类染色体 22q11.1 并普遍表达并表现出广泛的组织分布[1][2]。
IL-17RA 与 IL-17RC 配对以将 IL-17A 或 IL-17F 作为共价同源二聚体结合，但也将 IL-17A/IL-17F 作为异源二聚体结合。IL-17RA 在宿主防御机制中发挥重要作用，因此可提供针对病原体感染的保护。IL-17A/IL-17RA 轴与几种急性和慢性气道和肺部疾病的发病机制有关。IL-17RA 在许多炎症和自身免疫性疾病如类风湿性关节炎中发挥致病作用。IL-17RA 参与抗菌宿主防御和维持组织完整性。IL17RA 的缺陷是 5 型家族性念珠菌病 (CANDF5) 的原因。因此，IL17RA 缺乏可能导致慢性皮肤黏膜念珠菌病的风险[1][2][3][4]。

Interleukin-17 receptor A (IL-17RA), also known as CD217, is a cytokine receptor that binds interleukin 17. IL-17RA is a proinflammatory cytokine secreted by activated T-lymphocytes. IL-17 receptor family is composed of five members from IL-17RA to IL-17RE. The subunit IL-17RA is ubiquitous and is a common co-receptor subunit for other members of the IL-17 family. The IL-17RA gene is mapped to human chromosome 22q11.1 and is expressed ubiquitously and exhibits a broad tissue distribution[1][2].
IL-17RA pairs with IL-17RC to bind either IL-17A or IL-17F as covalent homodimers, but also IL-17A/IL-17F as heterodimers. IL-17RA offers protection against pathogenic infection as it plays an important role in host defence mechanism. The IL-17A/IL-17RA axis has been implicated in the pathogenesis of several acute and chronic airway and lung diseases. IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL-17RA involved in antimicrobial host defense and maintenance of tissue integrity. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5). IL17RA deficiency might lead to the risk of chronic mucocutaneous candidiasis[1][2][3][4].

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