强迫游泳实验（FST，Forced Swim Test）是一种常用于评估小鼠或大鼠情绪状态和抗抑郁药物效果的实验。在实验中，动物被迫在水中游泳一段时间，其后续的浮出水面和动作被用作衡量抑郁样行为的指标。抗抑郁药物通常能够延长动物的游泳时间，被认为具有抗抑郁效果。FST广泛用于药物筛选和了解抑郁症状的神经生物学基础，但也受到一些伦理和方法学的争议。

The forced swim test (FST) is an experiment commonly used to evaluate the emotional state and the effect of antidepressant drugs in mice or rats. In experiments, animals are forced to swim in water for a period of time, and their subsequent surfacing and movements are used as a measure of depressive-like behavior. Antidepressant drugs often extend the swimming time of animals and are considered to have antidepressant effects. FST is widely used for drug screening and understanding the neurobiological basis of depressive symptoms, but it is also subject to some ethical and methodological controversies.