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肝癌建模

肝癌建模是用于研究和模拟肝癌发生、发展和治疗的实验过程。常用的肝癌模型包括化学诱导、基因编辑、患者来源的移植模型、患者衍生的肿瘤模型等。这些模型可提供理解肝癌生物学和评估潜在治疗策略的平台。化学诱导模型通过给予动物致癌物质诱导肝癌,基因编辑模型通过改变关键基因模拟肝癌突变。肝癌建模为肿瘤生物学研究和药物开发提供了重要工具。


Liver cancer modeling is an experimental process used to study and simulate the occurrence, development, and treatment of liver cancer. Commonly used liver cancer models include chemical induction, gene editing, patient-derived transplant models, patient-derived tumor models, etc. These models may provide a platform to understand liver cancer biology and evaluate potential therapeutic strategies. The chemical induction model induces liver cancer by giving animals carcinogens, and the gene editing model simulates liver cancer mutations by changing key genes. Liver cancer modeling provides an important tool for tumor biology research and drug development.

相关实验方案

  • 肝癌可分为原发性肝癌和继发性肝癌。继发性肝癌是指转移性肝癌。原发性肝癌包括肝细胞癌 (HCC)、肝内胆管癌 (ICC) 和纤维板层 HCC,其中 HCC 是最常见的形式,约占原发性肝癌的 90%[1]。HCC 小鼠模型包括化学毒性试剂诱导模型、移植瘤模型和基因工程模型。