2. Metabolic Enzyme/Protease
  3. Proteasome
  4. PSI

PSI  (Synonyms: Proteasome Inhibitor 1; Z-Ile-Glu(OtBu)-Ala-Leu-CHO)

目录号: HY-P1258 纯度: ≥97.0%
COA 产品使用指南 技术支持

PSI (Proteasome Inhibitor 1) 是一种有效的蛋白酶体 proteasome 抑制剂。PSI 抑制原发性渗出性淋巴瘤 (PEL) 细胞的增殖。PSI具有研究卡波济氏肉瘤相关疱疹病毒 (KSHV) 感染和 KSHV 相关淋巴瘤的潜力。

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Custom Peptide Synthesis

PSI Chemical Structure

PSI Chemical Structure

CAS No. : 158442-41-2

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规格 价格 是否有货 数量
1 mg ￥1100
In-stock
5 mg ￥3200
In-stock
10 mg ￥5400
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of PSI:

PSI 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PSI (Proteasome Inhibitor 1) is a potent proteasome inhibitor. PSI inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI has the potential for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas[1].

体外研究
(In Vitro)

PSI (24 h) inhibits the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively)[1].
PSI (50 nM; 6 h) increases caspase-3/7 activity by 8-fold compared with control[1].
PSI (50 nM; 6 h) decreases the transcriptional activity of NF-κB by 52%[1].
PSI (1, 5 nM; 3 days) inhibits the growth of BC3 cells at a high concentration (5 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PSI 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: BC3, BCBL1, Ramos, BJAB cells
Concentration:
Incubation Time: 24 h
Result: Inhibited the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively).

Western Blot Analysis[1]

Cell Line: HBL6 cells
Concentration: 50 nM
Incubation Time: 6 h
Result: Decreased the NF-κB activity by 52%.
Clinical Trial
分子量

618.76

Formula

C32H50N4O8
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : < 0.1 mg/mL (adjust pH to 2 with Acetic acid) (insoluble)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥97.0%

COA (286 KB)

产品使用指南 (1538 KB)
参考文献

PSI 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSI158442-41-2Proteasome Inhibitor 1 Z-Ile-Glu(OtBu)-Ala-Leu-CHOProteasome Inhibitor1Proteasome Inhibitor-1ProteasomePrimary effusion lymphoma (PEL)apoptosisHBL6 cellsBC3 cellsNF-κBKSHVInhibitorinhibitorinhibit

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目录号：
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