2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. PTP1B-IN-18

PTP1B-IN-18 是一种具有口服活性的完全混合型蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，其 Ki 值为 35.2 μM。PTP1B-IN-18 可用于 2 型糖尿病的研究。

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PTP1B-IN-18 Chemical Structure

PTP1B-IN-18 Chemical Structure

CAS No. : 2848581-84-8

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PTP1B-IN-18 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PTP1B-IN-18 is an orally active complete mixed type protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 35.2 μM. PTP1B-IN-18 can be used for type 2 diabetes research[1].

IC50 & Target

ki: 35.2 μM (PTP1B)[1]
体内研究
(In Vivo)

PTP1B-IN-18 (Compound 44; 100 mg/kg; p.o.; single administration) reduces 23% of the blood sugar level[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Wistar rats weighing 200-250 g (type 2 diabetic rat model)[1]
Dosage: 100 mg/kg
Administration: Oral administration; single administration
Result: Showed hypoglycemic effect under physiological conditions.
分子量

469.51

Formula

C26H19N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PTP1B-IN-18 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTP1B-IN-182848581-84-8Phosphatasehypoglycemictype 2 diabetesbenzimidazole derivativesenzyme inhibitionInhibitorinhibitorinhibit

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目录号：
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