2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. PU24FCl

PU24FCl 是一种特异性的 Hsp90 抑制剂。PU24FCl 具有广泛的抗癌活性。PU24FCl 在肿瘤中积聚，同时从正常组织中迅速清除。

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PU24FCl Chemical Structure

PU24FCl Chemical Structure

CAS No. : 422508-46-1

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PU24FCl 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PU24FCl is a specific inhibitor of Hsp90. PU24FCl exhibits wide-ranging anti-cancer activities. PU24FCl accumulates in tumors while being rapidly cleared from normal tissue[1].

IC50 & Target[1]

HSP90

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
1.2 μM
Compound: PUC24FCI
Antiproliferative activity against human MCF7 cells by MTS assay
Antiproliferative activity against human MCF7 cells by MTS assay
[PMID: 17488003]
SK-BR-3 IC50
0.66 μM
Compound: PU24FCl
Displacement of GM-cy3B from Hsp90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay
Displacement of GM-cy3B from Hsp90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay
[PMID: 24548207]
SK-BR-3 IC50
2 μM
Compound: PU24FCl
Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by Western blotting analysis
Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by Western blotting analysis
[PMID: 24548207]
SK-BR-3 IC50
2.5 μM
Compound: PU24FCl
Inhibition of Hsp70 in human SKBR3 cells assessed as RAF1 protein degradation by Western blotting analysis
Inhibition of Hsp70 in human SKBR3 cells assessed as RAF1 protein degradation by Western blotting analysis
[PMID: 24548207]
SK-BR-3 IC50
2.9 μM
Compound: PU24FCl
Growth inhibition of human SKBR3 cells after 72 hrs by Alamar Blue assay
Growth inhibition of human SKBR3 cells after 72 hrs by Alamar Blue assay
[PMID: 24548207]
分子量

433.86

Formula

C20H21ClFN5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PU24FCl 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PU24FCl422508-46-1HSPHeat shock proteinsanticancerInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-11039
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