2. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  3. FLT3 Drug Metabolite
  4. (R)-3-Hydroxy Midostaurin

(R)-3-Hydroxy Midostaurin  (Synonyms: (R)-CGP52421)

目录号: HY-108263B
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摩尔计算器

(R)-3-Hydroxy Midostaurin ((R)-CGP52421) 是有效的激酶抑制剂。(R)-3-Hydroxy Midostaurin 是 Midostaurin (PKC412; HY-10230) 通过肝 CYP3A4 酶代谢的主要代谢产物。(R)-3-Hydroxy Midostaurin 具有潜在的用于急性髓细胞性白血病 (AML) 的潜力。

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(R)-3-Hydroxy Midostaurin Chemical Structure

(R)-3-Hydroxy Midostaurin Chemical Structure

CAS No. : 155848-20-7

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Other Forms of (R)-3-Hydroxy Midostaurin:

(R)-3-Hydroxy Midostaurin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].

体外研究
(In Vitro)

(R)-3-Hydroxy Midostaurin ((R)-CGP52421; compound 5) has IC50 values in the range of 200-400 nM against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme[1].
The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI50=63 nM), KIT D816V (GI50=320 nM), and FLT3-ITD (GI50=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-3-Hydroxy Midostaurin 相关抗体:
分子量

586.64

Formula

C35H30N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(R)-3-Hydroxy Midostaurin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-3-Hydroxy Midostaurin155848-20-7(R)-CGP52421FLT3Drug MetaboliteCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3VEGFR-2LTKPDPK1metabolitemidostaurinPKC412hepaticCYP3A4enzymeacutemyeloidleukemiaAMLInhibitorinhibitorinhibit

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