2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. 3-Hydroxy Midostaurin

3-Hydroxy Midostaurin  (Synonyms: CGP52421)

目录号: HY-108263 纯度: 97.02%
COA 产品使用指南

摩尔计算器

3-Hydroxy Midostaurin (CGP 52421) 是 PKC412 的代谢产物，可有效抑制 FMS 样酪氨酸激酶 3 (FLT3) 自磷酸化，在培养基和血浆中的 IC50 分别为 132 nM 和 9.8 μM。与 PKC412 相比，3-Hydroxy Midostaurin 的选择性较低，但细胞毒性更高。

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3-Hydroxy Midostaurin Chemical Structure

3-Hydroxy Midostaurin Chemical Structure

CAS No. : 179237-49-1

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1 mg ￥4680
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Other Forms of 3-Hydroxy Midostaurin:

3-Hydroxy Midostaurin 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].

IC50 & Target

IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)[1]
体外研究
(In Vitro)

CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3-Hydroxy Midostaurin 相关抗体:
分子量

586.64

Formula

C35H30N4O5
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

3-Hydroxy Midostaurin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

3-Hydroxy Midostaurin179237-49-1CGP52421CGP 52421CGP-52421FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Inhibitorinhibitorinhibit

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