2. 天然产物
  3. 疾病研究领域 植物 酚类 酮、醛、酸
  4. 心血管 其他科 多酚类
  5. (R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone 

目录号: HY-N8178
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摩尔计算器

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone 是一种类黄酮，具有抗人视网膜微血管内皮细胞的血管生成活性。

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(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone Chemical Structure

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone Chemical Structure

CAS No. : 849727-88-4

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(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, a homoisoflavonoid, has antiangiogenic activity against human retinal microvascular endothelial cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 100 μM
Compound: 18
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 19689125]
B16-BL6 IC50
> 100 μM
Compound: 18
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
[PMID: 19689125]
HeLa IC50
> 100 μM
Compound: 18
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 19689125]
HT-1080 IC50
> 100 μM
Compound: 18
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
[PMID: 19689125]
HT-29 IC50
> 20 μM
Compound: 7
Cytotoxicity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs
Cytotoxicity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs
[PMID: 26147490]
HUVEC GI50
> 100 μM
Compound: 7; 21
Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
[PMID: 30951308]
MDA-MB-435 IC50
> 20 μM
Compound: 7
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell growth incubated for 72 hrs
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell growth incubated for 72 hrs
[PMID: 26147490]
Y79 GI50
> 100 μM
Compound: 7; 21
Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
[PMID: 30951308]
体外研究
(In Vitro)

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone has an GI50 value of 35.8 μM on proliferation of human retinal microvascular endothelial cells (HRECs)[1].
(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone (10 μM, 30 μM, and 100 μM; 8 hours) significantly decreases HRECs overall tubule formation and in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone 相关抗体:
分子量

286.28

Formula

C16H14O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone849727-88-4OthersInhibitorinhibitorinhibit

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