2. Metabolic Enzyme/Protease
  3. Dopamine β-hydroxylase
  4. (R)-Nepicastat hydrochloride

(R)-Nepicastat hydrochloride  (Synonyms: (R)-SYN117 hydrochloride; (R)-RS-25560-197 hydrochloride; RS-25560-198 hydrochloride)

目录号: HY-13289B
产品使用指南

摩尔计算器

(R)-Nepicastat hydrochloride 是 Nepicastat (HY-13289) 的异构体。Nepicastat (SYN117) 是一种选择性的，有效的，具有口服活性的多巴胺 β 羟化酶 (dopamine-beta-hydroxylase) 抑制剂。Nepicastat (SYN117) 对牛 (IC50=8.5 nM) 和人(IC50=9 nM) 多巴胺 β 羟化酶产生浓度依赖性抑制作用。Nepicastat (SYN117) 可越过血脑屏障。

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(R)-Nepicastat hydrochloride Chemical Structure

(R)-Nepicastat hydrochloride Chemical Structure

CAS No. : 195881-94-8

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Other Forms of (R)-Nepicastat hydrochloride:

(R)-Nepicastat hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(R)-Nepicastat hydrochloride is the isomer of Nepicastat (HY-13289). Nepicastat (SYN117) is a selective，potent，and orally active inhibitor of dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC50=8.5 nM) and human (IC50=9 nM) dopamine-beta-hydroxylase. Nepicastat (SYN117) can cross the blood-brain barrier (BBB)[1][2][3].

分子量

331.81

Formula

C14H16ClF2N3S
CAS 号
中文名称

(R)-内匹司他盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(R)-Nepicastat hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Nepicastat195881-94-8(R)-SYN117(R)-RS-25560-197RS-25560-198(R)-内匹司他盐酸盐Dopamine β-hydroxylaseDopamine beta-hydroxylaseDopamine beta-monooxygenaseDopamine β-monooxygenaseInhibitorinhibitorinhibit

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