(R)-Oxybutynin  (Synonyms: Aroxybutynin)

(R)-Oxybutynin (Aroxybutynin) is the racemic isomer of Oxybutynin and an orally active muscarinic receptor antagonist. (R)-Oxybutynin has antispasmodic, antimuscarinic, and anticholinergic activities and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used to study urinary incontinence caused by neurogenic bladder dysfunction^[1][2][3].

Muscarinic receptor, mAChR^[1][2]

Oxybutynin 的代谢是立体选择性的，它主要通过细胞色素 P450 3A4 广泛代谢，形成 NDO。(R)-Oxybutynin 在血浆中的浓度低于另一种对映异构体^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

357.49

C₂₂H₃₁NO₃

119618-21-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Smith ER, et al. Comparison of the antimuscarinic and antispasmodic actions of racemic oxybutynin and desethyloxybutynin and their enantiomers with those of racemic terodiline. Arzneimittelforschung. 1998 Oct;48(10):1012-8.  [Content Brief]

  [2]. Siddiqui MA, et al. Oxybutynin extended-release: a review of its use in the management of overactive bladder. Drugs. 2004;64(8):885-912.  [Content Brief]

  [3]. Zobrist RH, et al. Pharmacokinetics of the R- and S-enantiomers of oxybutynin and N-desethyloxybutynin following oral and transdermal administration of the racemate in healthy volunteers. Pharm Res. 2001 Jul;18(7):1029-34.  [Content Brief]