2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. (R,R)-THC

(R,R)-THC 是 ERα 激动剂与 ERβ 拮抗剂，对 ERα 和 ERβ 的 Ki 分别为 9.0 nM 与 3.6 nM。(R,R)-THC 对 ERβ 有更高的亲和力，对 ERβ 和 ERα 的相对结合亲和力值分别为 25 与 3.6。

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(R,R)-THC Chemical Structure

(R,R)-THC Chemical Structure

CAS No. : 221368-54-3

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(R,R)-THC 相关抗体

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6[1].

IC50 & Target[1]

ERα

9.0 nM (Ki)

ERβ

3.6 nM (Ki)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 EC50
8.6 μM
Compound: 14
Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation after 16 hrs by luciferase reporter gene assay
Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation after 16 hrs by luciferase reporter gene assay
[PMID: 23688559]
分子量

320.42

Formula

C22H24O2
CAS 号
性状

固体

颜色

Light yellow to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

(R,R)-THC 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R,R)-THC221368-54-3Estrogen Receptor/ERRTetrahydrochryseneRelative binding affinityInhibitorinhibitorinhibit

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