2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. (R)-Reticuline

(R)-Reticuline  (Synonyms: (R)-番荔枝碱)

目录号: HY-N1356A 纯度: 99.41%
COA 产品使用指南 技术支持

(R)-Reticuline 是 Reticuline (HY-N1356) 的异构体。Reticuline 通过 JAK2/STAT3 和 NF-κB 信号通路显示抗炎和心血管作用。Salutaridine 是吗啡生物合成的关键中间体。在于罂粟植物中 Salutaridine 可由 (R)-Reticuline 转化而来。转化系统依赖于膜结合细胞色素 P-450 酶，还需要还原辅因子 NADPH、分子氧等。

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(R)-Reticuline Chemical Structure

(R)-Reticuline Chemical Structure

CAS No. : 3968-19-2

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Other Forms of (R)-Reticuline:

(R)-Reticuline 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(R)-Reticuline is an isomer of Reticuline (HY-N1356). Reticuline displays anti-inflammatory and cardiovascular effects through JAK2/STAT3 and NF-κB signaling pathways. Salutaridine is a key intermediate in morphine biosynthesis. Salutaridine can be converted from (R)-Reticuline in the poppy plant. The conversion system relies on membrane-bound cytochrome P-450 enzymes and also requires reducing cofactors NADPH, molecular oxygen, etc[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 30 μM
Compound: 6
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
[PMID: 20594848]
HCT-15 IC50
26.83 μM
Compound: 6
Cytotoxicity against human HCT15 cells by SRB assay
Cytotoxicity against human HCT15 cells by SRB assay
[PMID: 20594848]
SK-MEL-2 IC50
> 30 μM
Compound: 6
Cytotoxicity against human SK-MEL-2 cells by SRB assay
Cytotoxicity against human SK-MEL-2 cells by SRB assay
[PMID: 20594848]
SK-OV-3 IC50
> 30 μM
Compound: 6
Cytotoxicity against human SKOV3 cells by SRB assay
Cytotoxicity against human SKOV3 cells by SRB assay
[PMID: 20594848]
分子量

329.39

Formula

C19H23NO4
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

(R)-番荔枝碱；(R)-牛心果碱
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

(R)-Reticuline 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Reticuline3968-19-2(R)-番荔枝碱(R)-牛心果碱Cytochrome P450CYPsInhibitorinhibitorinhibit

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