2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. Dopamine Receptor Potassium Channel
  4. (R)-SKF 38393 hydrochloride

(R)-SKF 38393 hydrochloride  (Synonyms: (±)-SKF-38393 hydrochloride; SKF-38393A hydrochloride)

目录号: HY-12520B
产品使用指南 技术支持

(R)-SKF 38393 hydrochloride 是一种有效的选择性 D1 多巴胺受体拮抗剂。(R)-SKF 38393 hydrochloride 抑制 G 蛋白偶联内向整流钾 (GIRK) 通道。

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(R)-SKF 38393 hydrochloride Chemical Structure

(R)-SKF 38393 hydrochloride Chemical Structure

CAS No. : 81702-42-3

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规格 价格 是否有货 数量
1 mg ￥2236
1 - 2 周
5 mg ￥5589
1 - 2 周
10 mg   询价  
50 mg   询价  

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Customer Review

Other Forms of (R)-SKF 38393 hydrochloride:

(R)-SKF 38393 hydrochloride 相关抗体

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查看 Dopamine Receptor 亚型特异性产品:

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
56 nM
Compound: 2, SKF-38393
Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins
Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins
[PMID: 21862338]
体外研究
(In Vitro)

(R)-SKF 38393 HydroHClide ((±)-SKF-38393; 0-100 µM) 阻断 AtT-20 细胞中由生长抑素或 D3 多巴胺受体诱导的内源 GIRK 电流，IC50 值为 268 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-SKF 38393 hydrochloride 相关抗体:
分子量

291.77

Formula

C16H18ClNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(R)-SKF 38393 hydrochloride 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-SKF 3839381702-42-3(±)-SKF-38393SKF-38393ADopamine ReceptorPotassium ChannelKcsApotassium channelAtT-20 cellsGIRKInhibitorinhibitorinhibit

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目录号：
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