2. Apoptosis
  3. Bcl-2 Family
  4. (Rac)-BDA-366

(Rac)-BDA-366 (example 2) 是 BDA-366 (HY-101083) 的消旋体，BDA-366 是一种有效的 Bcl-2 拮抗剂 (Ki=3.3 nM)，对 Bcl-2-BH4 结构域具有较高的亲和力和选择性。BDA-366 诱导 Bcl-2 的构象改变，从而消除其抗凋亡功能，将 Bcl-2 从存活分子转化为细胞死亡诱导因子。BDA-366 可抑制肺癌细胞生长。

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(Rac)-BDA-366 Chemical Structure

(Rac)-BDA-366 Chemical Structure

CAS No. : 142645-19-0

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Other Forms of (Rac)-BDA-366:

(Rac)-BDA-366 相关抗体

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Rac)-BDA-366 (example 2) is the despinner of BDA-366 (HY-101083). BDA-366 is a potent Bcl-2 antagonist (Ki=3.3 nM), binding Bcl-2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl-2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells[1][2].

分子量

423.50

Formula

C24H29N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Rac)-BDA-366 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-BDA-366142645-19-0Bcl-2 FamilyInhibitorinhibitorinhibit

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产品名称：
(Rac)-BDA-366
目录号：
HY-101083A
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