2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. (Rac)-ErSO-DFP

(Rac)-ErSO-DFP 是一种 ErSO-DFP 的衍生物和选择性小分子 Erα 生物调节剂。(Rac)-ErSO-DFP 通过过度激活 ERα+ 依赖性的预期未折叠蛋白反应来发挥抗雌激素受体 α 阳性乳腺癌 (包括其抗性肿瘤) 的活性 (摘自专利 WO2022087234A1)。

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(Rac)-ErSO-DFP Chemical Structure

(Rac)-ErSO-DFP Chemical Structure

CAS No. : 2768139-73-5

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Other Forms of (Rac)-ErSO-DFP:

(Rac)-ErSO-DFP 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP againsts ERα+ breast cancer (including resistant tumors) by hyperactiving the Erα-dependent a-UPR (extracted from patent WO2022087234A1)[1].

IC50 & Target

IC50: 35 nM (MCF-7 cells)[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
0.035 μM
Compound: 2
Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay
Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay
[PMID: 35080871]
体外研究
(In Vitro)

(Rac)-ErSO-DFP (compound 2) (0.001-1 µM; 24 h) maintains potent anticancer activity with IC50 of 35 nM in MCF-7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(Rac)-ErSO-DFP 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-7 cells
Concentration: 0.001-1 µM
Incubation Time: 24 h
Result: Showed a sustained activity of anticancer with IC50 of 35 nM.
体内研究
(In Vivo)

(Rac)-ErSO-DFP (compound 2) (5 mg/kg; i.v.; 3xq.wk.) shows a sustained activity of againsting ERα+ breast cancer at low doses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ovariectomized Nu/J mice (MCF-7 orthotopic tumor model)[1].
Dosage: 5 mg/kg
Administration: Intravenous injection; once-a-week for 3 total doses.
Result: Maintained the ability to regress MCF-7 tumors in a mouse model of ERα+ breast cancer.
分子量

412.35

Formula

C20H17F5N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Rac)-ErSO-DFP 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-ErSO-DFP2768139-73-5Estrogen Receptor/ERRERαresistant tumorsbreast cancerErSO-DFPa-UPRInhibitorinhibitorinhibit

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目录号：
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