(Rac)-Melphalan-d₈  (Synonyms: (Rac)-美法仑-d₈)

(Rac)-Melphalan-d₈ is deuterium labeled Melphalan. Melphalan is an effective DNA alkylating agent, with potent antitumor activity.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

313.25

C₁₃H₁₀D₈Cl₂N₂O₂

148-82-3

(Rac)-美法仑-d₈；(Rac)-马法兰-d₈；(Rac)-马尔法兰-d₈；(Rac)-米尔法兰-d₈；(Rac)-左旋溶肉瘤素-d₈；(Rac)-左旋苯丙氨酸氮芥-d₈

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. BLUMBERG BS, et al. AN ALKYLATING AGENT FOR MULTIPLE MYELOMA: MELPHALAN. JAMA. 1965 Feb 15;191:547-9.  [Content Brief]

  [3]. Glehen O, et al. Hyperthermia modifies pharmacokinetics and tissue distribution of intraperitoneal melphalan in a rat model. Cancer Chemother Pharmacol. 2004 Jul;54(1):79-84.  [Content Brief]

  [4]. Rothbarth J, et al. Immunohistochemical detection of melphalan-DNA adducts in colon cancer cells in vitro and human colorectal liver tumours in vivo. Biochem Pharmacol. 2004 May 1;67(9):1771-8.  [Content Brief]