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  4. (±)5,6-DHET lactone

(±)5,6-DHET lactone  (Synonyms: (±)5,6-DiHETrE lactone)

目录号: HY-130229
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5,6-DiHET lactone ((±)5,6-DiHETrE lactone) 是 5,6-EET 和 5,6-DiHET 的内酯化形式。在溶液中，5(6)-EET 降解为 5(6)-DiHET 和 5(6)-δ-内酯，后者可转化为 5(6)-DiHET 并通过 GC-MS 定量。5,6-DiHET 可有效诱导分离的犬冠状动脉小动脉血管扩张，在 0.01 和 100 pM 时分别发生 41% 和 100% 的抑制。它还可诱导分离的人类微血管血管扩张并以剂量依赖性方式增加细胞内钙水平，这种作用可被一氧化氮清除剂 L-NAME 阻断。

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(±)5,6-DHET lactone Chemical Structure

(±)5,6-DHET lactone Chemical Structure

CAS No. : 213126-92-2

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(±)5,6-DHET lactone 相关抗体

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生物活性

5,6-DiHET lactone ((±)5,6-DiHETrE lactone) is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.1 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME.

分子量

320.47

Formula

C20H32O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
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(±)5,6-DHET lactone 相关分类

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Keywords:

(±)5,6-DHET lactone213126-92-2(±)5,6-DiHETrE lactoneOthersInhibitorinhibitorinhibit

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