1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. (±)8(9)-EpETE

(±)8(9)-EpETE  (Synonyms: (±)8,9-EEQ; (±)8,9-epoxy Eicosatetraenoic acid)

目录号: HY-130309
产品使用指南

(±)8(9)-EpETE ((±)8,9-EEQ; (±)8,9-epoxy Eicosatetraenoic acid) 可被多种细胞色素 P450 同工酶转化为环氧二十碳四烯酸 (EpETE)。该环氧化物途径的主要产物为 (±)17(18)-EpETE,它可直接与 BKα 通道亚基相互作用,激活大电导 Ca2+ 激活 K+ (BKCa) 通道,从而松弛血管和气道平滑肌。(±)8(9)-EpETE 是一种环氧化物途径产物,在体内和体外均由 CYP450 由 EPA 产生。

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(±)8(9)-EpETE Chemical Structure

(±)8(9)-EpETE Chemical Structure

CAS No. : 851378-93-3

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规格 价格 是否有货 数量
25 μg ¥1152
3 - 4 周
50 μg ¥2070
3 - 4 周
100 μg ¥3645
3 - 4 周

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Eicosapentaenoic acid (EPA) is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE, relaxes vascular and airway smooth muscle by activating large conductance Ca2+-activated K+ (BKCa) channels by directly interacting with BKα channel subunits. (±)8(9)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo.

分子量

318.45

Formula

C20H30O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
(±)8(9)-EpETE
目录号:
HY-130309
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