2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. PDI Phosphatase
  4. (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane

(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane 

目录号: HY-116748
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(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane 是一种具有低巯基 pKa 值 (8.3) 和高还原电位 (-0.24 V) 的二硫醇小分子催化剂，能够模拟 PDI 的活性。(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane 可催化去折叠核糖核酸酶 A (scrambled ribonuclease A) 活化，催化蛋白质的天然二硫键形成，从而显著提高蛋白质折叠效率。在酿酒酵母 (Saccharomyces cerevisiae) 的培养基中添加 (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane，可将外源表达的裂殖酵母酸性磷酸酶 (Schizosaccharomyces pombe acid phosphatase) 的分泌量提高三倍以上。(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane 在蛋白质生产与分泌研究中具有广泛的应用前景。

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(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane Chemical Structure

(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane Chemical Structure

CAS No. : 257641-01-3

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(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane 相关抗体

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  • 生物活性

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生物活性

(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane is a small-molecule dithiol catalyst with a low thiol pKa value (8.3) and high reduction potential (-0.24 V), capable of mimicking PDI activity. It catalyzes the activation of scrambled ribonuclease A (scrambled ribonuclease A) and promotes the formation of native disulfide bonds, thereby significantly enhancing protein folding efficiency. Adding (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane to the culture medium of Saccharomyces cerevisiae can increase the secretion of exogenously expressed Schizosaccharomyces pombe acid phosphatase by more than threefold. (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane holds great potential for applications in protein production and secretion research[1].

分子量

262.39

Formula

C10H18N2O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane 相关分类

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Keywords:

(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane257641-01-3PDIPhosphataseProtein Disulfide IsomerasesInhibitorinhibitorinhibit

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