2. Anti-infection
  3. Bacterial
  4. Raxibacumab

Raxibacumab  (Synonyms: 雷昔库单抗; ABthrax)

目录号: HY-P9957 纯度: 98.88%
COA

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Raxibacumab (ABthrax) 是一种针对炭疽杆菌 ( Bacillus anthracis ) 保护性抗原(PA)的人类 IgG1 单克隆抗体。Raxibacumab 通过阻止炭疽毒素中的保护性抗原成分与其在宿主细胞中的受体结合，从而阻断毒素的有害作用，可用于抗炭疽病研究。

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CAS No. : 565451-13-0

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规格 价格 是否有货 数量
1 mg ￥3000
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5 mg ￥7800
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Raxibacumab 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxin’s deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxin’s deleterious effects. Raxibacumab can be used for anti-anthrax research[1][2].

同型

Human IgG1 lambda1
推荐同型对照抗体
种属

Human
体内研究
(In Vivo)

Raxibacumab (150 μg/kg or 300 μg/kg，静脉注射，单次给药) 首次暴露于炭疽杆菌致死毒素 (LeTx) 后 6 小时内给药，显著改善大鼠预后[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: In SD rats after the initiation of a 24-h LeTx infusion[3]
Dosage: 150 μg/kg or 300 μg/kg
Administration: At the time of or 3, 6, 9, or 12 h after the initiation of LeTx infusion, the rats were randomized to be treated i.v. in a single dose
Result: Significantly improved in outcome when it was administered up to 6 h (and approached significance when administered up to 12 h) after initial exposure to LeTx.
Rats receiving raxibacumab within 6 hours of toxin administration had a better survival rate than those that received raxibacumab at 9 or 12 hours.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

雷昔库单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
纯度 & 产品资料
参考文献

Raxibacumab 相关分类

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  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Raxibacumab565451-13-0ABthrax雷昔库单抗BacterialAnthraxBacillus anthracisprotective antigenanti-Anthraxhuman IgG1 monoclonal antibodyInhibitorinhibitorinhibit

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