ADAM9 蛋白, Human (HEK293, His)

ADAM9, a metalloprotease, cleaves and releases TEK, KDR, EPHB4, CD40, VCAM1, and CDH5, playing a pivotal role in tumorigenesis and angiogenesis. It regulates cell motility through integrin interactions, mediates cell-cell and cell-matrix interactions, and may act as an alpha-secretase for APP, suggesting involvement in neurobiology and neurodegenerative disorders. ADAM9 Protein, Human (HEK293, His) is the recombinant human-derived ADAM9 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM9 Protein, Human (HEK293, His) is 669 a.a., with molecular weight of 40-45 kDa.

ADAM9 是一种金属蛋白酶，通过裂解和释放各种分子（包括 TEK、KDR、EPHB4、CD40、VCAM1 和 CDH5），在肿瘤发生和血管生成中发挥关键作用。其多方面的功能延伸到介导细胞-细胞和细胞-基质相互作用，从而通过与整合素的相互作用来调节细胞运动。此外，ADAM9 可能充当淀粉样前体蛋白 (APP) 的 α 分泌酶，突出显示其参与与神经生物学和神经退行性疾病相关的过程。

Measured by its ability to cleave a fluorogenic peptidesubstrate Mca-PLAQAV-Dpa-RSSSR-NH. The specificactivity is 6.85 pmol/min/ug.

Human

HEK293

C-His

Q13443 (A29-D697)

8754  [NCBI]

40-45 kDa and 60-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, 500 mM NaCl, 0.005% Brij-35,20% Glycerol (pH8.5).

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.