2. Gene
  3. ADAM9 - ADAM metallopeptidase domain 9 Gene

ADAM9 - ADAM metallopeptidase domain 9 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ADAM 金属肽酶域 9

种属: Homo sapiens

同用名: MCMP; MDC9; CORD9; Mltng

基因 ID: 8754 | 基因类型: protein coding

关于 ADAM9

Cytogenetic location: 8p11.22 Genomic coordinates (GRCh38): 8:38,996,973-39,105,261 (from NCBI)

This gene has 28 transcripts (splice variants), 1 gene allele, 211 orthologues, 20 paralogues and is associated with 3 phenotypes. Ubiquitous expression in gall bladder (RPKM 19.8), urinary bladder (RPKM 16.8) and 24 other tissues.

功能概要

该基因编码 ADAM (一种去整合素和金属蛋白酶结构域) 家族的成员。该家族的成员是膜锚定蛋白，在结构上与蛇毒解离蛋白相关，并且涉及涉及细胞-细胞和细胞-基质相互作用的各种生物过程，包括受精、肌肉发育和神经发生。由该基因编码的蛋白质与包含 SH3 结构域的蛋白质相互作用，结合有丝分裂停滞缺陷的 2 β 蛋白质，并且还参与 TPA 诱导的膜锚定肝素结合 EGF 样生长因子的胞外域脱落。已经为该基因鉴定了几种选择性剪接的转录物变体。[RefSeq 提供，2010 年 7 月]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

ADAM9 基因产物(1)

mRNA Protein Name
NM_003816.3 NP_003807.1 disintegrin and metalloproteinase domain-containing protein 9 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
10531379 GOA
enables collagen binding IMP
IMP: 通过突变表型推断
15361064 GOA
enables integrin binding IDA
IDA: 通过直接分析推断
15361064 GOA
enables integrin binding IPI
IPI: 通过物理相互作用推断
17704059 GOA
enables laminin binding IMP
IMP: 通过突变表型推断
15361064 GOA
enables metalloendopeptidase activity IDA
IDA: 通过直接分析推断
9920899 GOA
enables metalloendopeptidase activity IMP
IMP: 通过突变表型推断
22480688 GOA
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process IDA
IDA: 通过直接分析推断
12054541 GOA
enables metallopeptidase activity IMP
IMP: 通过突变表型推断
12535668 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10527948 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid precursor protein catabolic process IDA
IDA: 通过直接分析推断
12054541 GOA
involved in cell adhesion IMP
IMP: 通过突变表型推断
11162558 GOA
involved in cell adhesion mediated by integrin IMP
IMP: 通过突变表型推断
17704059 GOA
involved in cell-cell adhesion mediated by integrin IEP
IEP: 通过表达模式推断
17704059 GOA
involved in cell-matrix adhesion IMP
IMP: 通过突变表型推断
15361064 GOA
involved in cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
22480688 GOA
involved in keratinocyte differentiation IEP
IEP: 通过表达模式推断
17704059 GOA
involved in membrane protein ectodomain proteolysis IDA
IDA: 通过直接分析推断
9920899 GOA
acts upstream of or within membrane protein ectodomain proteolysis IMP
IMP: 通过突变表型推断
23437250 GOA
involved in membrane protein ectodomain proteolysis IMP
IMP: 通过突变表型推断
22480688 GOA
acts upstream of or within membrane protein intracellular domain proteolysis IMP
IMP: 通过突变表型推断
23437250 GOA
involved in monocyte activation IMP
IMP: 通过突变表型推断
11831872 GOA
acts upstream of positive regulation of MAP kinase activity IDA
IDA: 通过直接分析推断
17704059 GOA
involved in positive regulation of cell adhesion mediated by integrin IMP
IMP: 通过突变表型推断
11162558 GOA
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
23437250 GOA
involved in positive regulation of keratinocyte migration IMP
IMP: 通过突变表型推断
17704059 GOA
involved in positive regulation of macrophage fusion IMP
IMP: 通过突变表型推断
11831872 GOA
involved in positive regulation of protein secretion IDA
IDA: 通过直接分析推断
17704059 GOA
involved in protein processing IDA
IDA: 通过直接分析推断
12054541 GOA
involved in response to calcium ion IMP
IMP: 通过突变表型推断
11162558 GOA
involved in response to hydrogen peroxide IMP
IMP: 通过突变表型推断
17018608 GOA
involved in response to manganese ion IMP
IMP: 通过突变表型推断
11162558 GOA
involved in response to tumor necrosis factor IDA
IDA: 通过直接分析推断
11831872 GOA
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
11955914 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
12054541 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADAM9 蛋白结构

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (43 - 163)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (212 - 406)

Disintegrin

Disintegrin: Disintegrin (423 - 498)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (501 - 617)

  • 0
  • 200
  • 400
  • 600
  • 819 a.a.
蛋白主名 其他名称

disintegrin and metalloproteinase domain-containing protein 9

ADAM metallopeptidase domain 9 (meltrin gamma)

ADAM9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ADAM9 Q13443 SNX18 Homo sapiens Q96RF0
Peptide Array
25825872
种属内
ADAM9 Q13443 SNX18 Homo sapiens Q96RF0
Phage Display
25825872
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ADAM9 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77867 ADAM9 Protein, Human (HEK293, His, solution) Q13443 (A29-D697) ≥95%

关联疾病

疾病名称 别名
Cone-Rod Dystrophy 9

CORD9

Dystrophy, Cone-Rod, Type 9

Retinitis Pigmentosa 9
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Retinal Degeneration

Degeneration Of Retina
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Gastroesophageal Reflux

Gastroesophageal Reflux Disease

Gerd

GER

Gastroesophageal Reflux, Pediatric

Acid Reflux

Gastresophageal Reflux

Gastro-Esophageal Reflux

Gerd - Gastro-Esophageal Reflux Disease
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P990027 Izeltabart 98.03% Phase 2
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P3722A Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 99.21% 否
HY-P3722 Mca-PLAQAV-Dpa-RSSSR-NH2 / 否
HY-RS00289 ADAM9 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ADAM9 VGNC VGNC:59585
Mus musculus ADAM9 MGD MGI:105376
Bos taurus ADAM9 VGNC VGNC:25613
Macaca mulatta ADAM9 VGNC VGNC:82097
Rattus norvegicus ADAM9 RGD RGD:621473
Canis familiaris ADAM9 VGNC VGNC:37588
Others ADAM9 NCBI
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