2. 重组蛋白
  3. Enzymes & Regulators
  4. Oxidoreductases (EC 1)
  5. ADH4 蛋白, Human (GST)

ADH4 蛋白, Human (GST)

目录号: HY-P701927
产品使用指南

ADH4 蛋白是一种酶，参与酒精和其他有毒化合物的代谢。ADH4 蛋白的失调与酒精引起的肝损伤和对某些疾病的易感性有关。靶向 ADH4 蛋白可能通过调节酒精代谢、防止肝损伤和降低疾病风险来提供潜在的治疗干预措施。ADH4 蛋白, Human (GST) 是重组的 ADH4 蛋白，由 E. coli 表达，带有 N-GST 标签。ADH4 蛋白, Human (GST) 全长 380 个氨基酸。

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描述

ADH4 Protein, an enzyme, is involved in the metabolism of alcohol and other toxic compounds. Dysregulation of ADH4 Protein has been linked to alcohol-induced liver damage and susceptibility to certain diseases. Targeting ADH4 Protein may offer potential therapeutic interventions by modulating alcohol metabolism, protecting against liver damage, and reducing disease risk. ADH4 Protein, Human (GST) is the recombinant human-derived ADH4 protein, expressed by E. coli , with N-GST labeled tag. The total length of ADH4 Protein, Human (GST) is 380 a.a., .
研究背景

ADH4 蛋白表现出依赖于 NAD 的催化活性，能够氧化全反式视黄醇或 9-顺式视黄醇。此外，据观察，它可以氧化长链 omega-羟基脂肪酸，包括 20-HETE，从而产生中间体醛、20-氧代花生四烯酸酯和最终产物，一种称为 (5Z,8Z, 11Z,14Z)-二十碳四烯二酸酯。此外，ADH4 蛋白参与苯醌的还原。
种属

Human
表达系统

E. coli
标签

N-GST
蛋白编号

P08319 (M1-F380)
基因 ID

127
蛋白结构
N-term
GST
ADH4 (M1-F380)
Accession # P08319
C-term
同用名
ADH4; All-trans-retinol dehydrogenase [NAD(+)] ADH4; Alcohol dehydrogenase 4; Alcohol dehydrogenase class II pi chain
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

ADH4 Protein, Human (GST) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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