Adrenomedullin/ADM 蛋白, Human (HEK293, Fc)

Adrenomedullin (ADM) and PAMP serve as potent hypotensive and vasodilatory agents, mainly influencing fluid and electrolyte homeostasis. In the kidney, ADM demonstrates diuretic and natriuretic effects, while both ADM and PAMP directly inhibit aldosterone secretion in the adrenal glands. In the pituitary gland, both peptides suppress basal ACTH secretion at physiologically relevant doses. Additionally, ADM and PAMP act in the brain and pituitary gland, promoting plasma volume loss, complementing their hypotensive effects. These multifaceted actions highlight ADM's role in regulating cardiovascular and hormonal processes related to fluid and electrolyte balance. Adrenomedullin/ADM Protein, Human (HEK293, Fc) is the recombinant human-derived Adrenomedullin/ADM protein, expressed by HEK293, with N-hFc labeled tag. The total length of Adrenomedullin/ADM Protein, Human (HEK293, Fc) is 52 a.a., with molecular weight of ~39 kDa.

肾上腺髓质素 (ADM) 和 PAMP 是有效的降血压和血管舒张剂，具有许多报道的作用，主要与体液和电解质稳态的生理控制有关。在肾脏中，ADM 具有利尿和利尿钠作用，而 ADM 和 PAMP 均通过直接作用于肾上腺来抑制醛固酮分泌。在垂体中，这两种肽在生理相关剂量下都会抑制基础 ACTH 分泌。此外，ADM 和 PAMP 似乎在大脑和垂体中起作用，促进血浆容量的损失，这些作用补充了它们在血管中的降血压作用。这些多方面的作用强调了 ADM 在调节与液体和电解质平衡相关的心血管和激素过程中的作用。

Human

HEK293

N-hFc

P35318 (Y95-Y146)

133  [NCBI]

YRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGY

Approximately 39 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.