AG-2 蛋白, Mouse (HEK293, His)

AG-2 protein is essential for the post-transcriptional synthesis and secretion of MUC2, a key component of mucus.It plays an important role in intestinal cell mucus production and is considered a proto-oncogene with potential effects on cell migration, differentiation and growth.AG-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived AG-2 protein, expressed by HEK293 , with C-His labeled tag.

AG-2 蛋白对于 MUC2（粘液的关键成分）的转录后合成和分泌至关重要。据信它在肠细胞产生粘液中具有重要作用。此外，AG-2 被认为是一种原癌基因，可能影响细胞迁移、细胞分化和细胞生长。它还促进细胞粘附。AG-2以单体和同型二聚体形式存在。此外，它与 LYPD3 和 DAG1 (alphaDAG1) 蛋白相互作用，并与 MUC2 形成二硫键连接的相互作用。

Measured by the ability of the immobilized protein to support the adhesion of PC-3 human prostate cancer cells. The ED₅₀ for this effect is 0.9917 μg/mL, corresponding to a specific activity is 1008.370 units/mg.

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  Measured by the ability of the immobilized protein to support the adhesion of PC-3 human prostate cancer cells. The ED₅₀ for this effect is 0.9917 μg/mL, corresponding to a specific activity is 1008.370 units/mg.

Mouse

HEK293

C-His

O88312 (K21-L175)

23795  [NCBI]

KDTTVKSGAKKDPKDSRPKLPQTLSRGWGDQLIWTQTYEEALYRSKTSNRPLMVIHHLDECPHSQALKKVFAEHKEIQKLAEQFVLLNLVYETTDKHLSPDGQYVPRIVFVDPSLTVRADITGRYSNRLYAYEPSDTALLYDNMKKALKLLKTEL

approximately 20-22 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, 1 mM TCEP, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.