PARVA/alpha-Parvin 蛋白, Human (His)

alpha-Parvin Protein, Human (His) is a recombinant human alpha-Parvin with a His tag at the C-terminus. Alpha-parvin is an essential regulator of actin-dependent processes, such as cell spreading and migration^[1].

Alpha-parvin (α-parvin；α-pv) 广泛表达，是肌动蛋白依赖性过程（例如细胞扩散和迁移）的重要调节因子。Alpha-parvin 是一种将整合素与肌动蛋白细胞骨架偶联的粘着斑蛋白，对于表皮形态发生和 HF 发育至关重要。Alpha-parvin 通过调节 RhoA/ROCK 信号传导^[1][2]来控制血管壁细胞向血管壁的募集。

Human

E. coli

C-6*His

Q9NVD7-1 (M1-E372)

55742  [NCBI]

MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSELQEEGMNAINLPLSPIPFELDPEDTMLEENEVRTMVDPNSRSDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKSLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVEHHHHHH

Approximately 50 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filter solution of 50 mM Tris, 150 mM NaCl, 40% Glycerol, pH 7.4 or 50 mM Tris-HCL, 300 mM NaCL, pH 7.4, 10% Glycerol.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. Altstätter J, et al. α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity. PLoS One. 2020 Mar 12;15(3):e0230380.  [Content Brief]

  [2]. Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling. EMBO J. 2009 Oct 21;28(20):3132-44.  [Content Brief]