Aminopeptidase A 蛋白, Mouse (sf9, His)

The aminopeptidase A protein is a key player in the regulation of central hypertension, exerting its effects by selectively cleaving the N-terminal acidic residues of peptides such as angiotensin II. The enzyme's preference for specific substrates is regulated by calcium levels, underscoring its critical role in controlling blood pressure and maintaining cardiovascular health. Aminopeptidase A Protein, Mouse (sf9, His) is the recombinant mouse-derived Aminopeptidase A protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Aminopeptidase A Protein, Mouse (sf9, His) is 905 a.a., with molecular weight of ~113 kDa.

氨基肽酶 A 蛋白是调节中枢性高血压的关键参与者，通过选择性切割血管紧张素 II 等肽的 N 末端酸性残基来发挥其影响。该酶对特定底物的偏好受钙水平的调节，强调了其在控制血压和维持心血管健康方面的关键作用。氨肽酶A蛋白通过裂解肽，影响血管活性物质的平衡，最终有助于血管张力和血压的调节。了解这种蛋白质的复杂机制和功能意义可以为高血压相关疾病的靶向治疗的开发提供有价值的见解。

Measured by its ability to cleave the fluorogenic peptide substrate, Glu-7-amido-4-methyl coumarin and the specific activity is > 200 pmoles/min/μg.

Mouse

Sf9 insect cells

N-His

P16406 (R41-P945)

13809  [NCBI]

RSCEQDTTPAPSQPPPEASTALPPQDQNVCPDSEDESGEWKNFRLPDFINPVHYDLEVKALMEEDRYTGIVTISVNLSKPTRDLWLHIRETKITKLPELRRPSGEQVPIRRCFEYKKQEYVVIQAAEDLAATSGDSVYRLTMEFKGWLNGSLVGFYKTTYMEDGQIRSIAATDHEPTDARKSFPCFDEPNKKSTYSISIIHPKEYSALSNMPEEKSEMVDDNWKKTTFVKSVPMSTYLVCFAVHRFTAIERKSRSGKPLKVYVQPNQKETAEYAANITQAVFDYFEDYFAMEYALPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQRVASVVAHELVHQWFGNTVTMDWWDDLWLNEGFASFFEFLGVNHAEKDWQMLSQVLLEDVFPVQEDDSLMSSHPVVVTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLKKFQFANAKTSDFWDSLQEASNLPVKEVMDTWTSQMGYPVVTVSGRQNITQKRFLLDSKADPSQPPSELGYTWNIPVRWADNDNSRITVYNRLDKGGITLNANLSGDAFLKINPDHIGFYRVNYEGGTWDWIAEALSSNHTRFSAADRSSFIDDAFALARAQLLNYKIALNLTMYLKSEEDFLPWERVISSVSYIISMFEDDRELYPMIETYFQGQVKPVADLLGWQDTGSHITKLLRASILGFACKMGDREALGNASQLFDSWLKGSASIPVNLRLLVYRYGMQNSGNEAAWNYTLEQYQKTSLAQEKEKLLYGLASVKDVKLLARYLEMLKDPNIIKTQDVFTVIRYISYNSYGKTMAWNWIQLNWDYLVSRFTINDRYLGRIVTIAEPFNTELQLWQMQSFFAKYPNAGAGAKPREQVLETVKNNIEWLNVNRQSIREWFASLP

Approximately 113 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.22 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.