Animal-Free BMP-12/GDF-7 蛋白, Human (His)

BMP-12/GDF-7 Protein, existing as a homodimer with disulfide linkages, is hypothesized to influence the motor area of the primate neocortex. Its distinct structural characteristics suggest a unique mode of action, possibly contributing to cellular events integral to motor area function. The precise details of BMP-12/GDF-7 Protein's role in this neural context and its implications in motor-related processes await further research. Animal-Free BMP-12/GDF-7 Protein, Human (His) is the recombinant human-derived animal-FreeBMP-12/GDF-7 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free BMP-12/GDF-7 Protein, Human (His) is 129 a.a., with molecular weight of ~14.95 kDa.

BMP-12/GDF-7 蛋白被认为发挥着积极作用，可能对灵长类动物新皮质的运动区域产生影响。该蛋白质作为具有二硫键的同二聚体存在，其运动区域内的具体机制和分子相互作用仍有待充分阐明。同型二聚体的独特结构特征表明其具有独特的作用模式，可能有助于灵长类新皮质运动区功能和调节中不可或缺的细胞事件。需要进一步的研究来揭示 BMP-12/GDF-7 蛋白在这种神经环境中的作用的精确细节及其在运动相关过程中的潜在影响。

Measure by its ability to induce alkaline phosphatase production by ATDC5 cells. The ED₅₀ for this effect is <112 ng/mL

Human

E. coli

C-His

Q7Z4P5 (T322-R450)

151449  [NCBI]

MTALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR

Approximately 14.95 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 3.5, trehalose.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.