GDF7 - growth differentiation factor 7 Gene

中文名称：生长分化因子 7

种属: Homo sapiens

同用名: BMP12

关于 GDF7

功能概要

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。编码的前原蛋白经过蛋白水解处理，生成二硫键连接的同型二聚体的每个亚基。这种蛋白质可能在肌腱细胞和脊髓中间神经元的分化中发挥作用。该基因的突变可能与巴雷特食管和食管腺癌的风险增加有关。[RefSeq 提供，2016 年 9 月]

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016]