Animal-Free IL-19 蛋白, Mouse (His)

The IL-19 protein functions as a multifaceted cytokine, acting as both an anti-inflammatory and a pro-angiogenic factor. It plays a key role in polarizing adaptive immunity toward an anti-inflammatory phenotype by inducing T helper 2 responses. Animal-Free IL-19 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-19 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-19 Protein, Mouse (His) is 152 a.a., with molecular weight of ~18.54 kDa.

IL-19 蛋白作为一种多方面的细胞因子发挥作用，既可作为抗炎因子，又可作为促血管生成因子。它通过诱导 T 辅助细胞 2 反应，在将适应性免疫极化为抗炎表型方面发挥着关键作用。这涉及下调 IFN-γ 和上调 IL4 和 IL5 的双重机制。IL-19 主要由骨细胞产生，可进一步刺激粒细胞生成和中性粒细胞的形成。其生物学效应是通过由 IL20RA 和 IL20RB 异二聚体组成的受体复合物介导的。结合后，IL-19 激活 Janus 激酶 (JAK) 以及信号转导子和转录激活子 (STAT) 途径，特别是 STAT3，从而发挥其多样化的免疫调节功能。

Measure by its ability to induce proliferation in BaF3 cells transfected with human IL-20 R alpha and human IL-20 R beta. The ED₅₀ for this effect is <0.6 ng/mL.

Mouse

E. coli

C-His

Q8CJ70 (L25-A176)

329244  [NCBI]

MLRRCLISVDMRLIEKSFHEIKRAMQTKDTFKNVTILSLENLRSIKPGDVCCMTNNLLTFYRDRVFQDHQERSLEVLRRISSIANSFLCVQKSLERCQVHRQCNCSQEATNATRIIHDNYNQLEVSSAALKSLGELNILLAWIDRNHLETPAA

Approximately 18.54 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.