Animal-Free IL-36RN 蛋白, Mouse (His)

IL-36RN Protein inhibits IL36A, IL36B and IL36G receptors by binding to IL1RL2/IL-36R, blocking their association with IL1RAP and inhibiting downstream signaling. It is an important component of the IL-36 signaling system and participates in the local inflammatory response of the epithelial barrier. Animal-Free IL-36RN Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-36RN protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-36RN Protein, Mouse (His) is 155 a.a., with molecular weight of ~17.81 kDa.

IL-36RN 蛋白通过与白细胞介素 36（IL36A、IL36B 和 IL36G）受体 IL1RL2/IL-36R 结合而发挥抑制剂作用，防止其与辅助受体 IL1RAP 结合并抑制下游信号传导。该蛋白是 IL-36 信号系统的重要组成部分，与局部炎症反应有关，特别是在上皮屏障中。IL-36RN 蛋白被认为在皮肤炎症中发挥作用，并有助于针对真菌病原体的先天免疫反应，它可能通过招募 SIGIRR 来激活抗炎信号通路。值得注意的是，它与货物受体 TMED10 相互作用，促进从细胞质易位至内质网-高尔基中间室 (ERGIC) 进行分泌。

Measure by its ability to inhibit IL-36 gamma-induced IL-6 secretion in 3T3 cells. The ED₅₀ for this effect is <2 µg/mL

Mouse

E. coli

C-His

Q9QYY1 (M2-D156)

54450  [NCBI]

MVLSGALCFRMKDSALKVLYLHNNQLLAGGLHAEKVIKGEEISVVPNRALDASLSPVILGVQGGSQCLSCGTEKGPILKLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPGWFLCTSPEADQPVRLTQIPEDPAWDAPITDFYFQQCD

Approximately 17.81 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.