1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-36

IL-36  (白细胞介素-36)

IL-36 由 3 个亚型组成,包括 IL-36α, IL-36β, IL-36γ,属于 IL-1 超家族。IL-36 通常以低水平表达。被刺激后,它们被诱导产生并作用于多种细胞,包括上皮细胞和免疫细胞。IL-36 介导炎症反应。但这种激活需要中性粒细胞来源的蛋白酶对 IL-36 alpha 的 N 端进行切割,如:组织蛋白酶 G (cathepsin G)、弹性蛋白酶 (elastase) 和蛋白酶 3 (proteinase-3) [1].
IL-36 alpha 与 IL-36R 结合并激活 NF-κB 和 MAPK 信号通路,从而介导炎症反应。IL-36 alpha 在单核细胞、T/B 淋巴细胞、脾脏、骨髓扁桃体、淋巴结和皮肤中表达[2]。L-36 beta 和 IL-36 gamma 可与 IL-36R 结合并募集辅助受体 IL-1RAcP。因此,所形成的异二聚体信号复合物使得 2 条受体链的 Toll/IL-1R (TIR) 结构域紧密靠近,从而激活 NF-κB 和 MAPK 信号通路[3]。IL-36 beta 在单核细胞、T/B 淋巴细胞、骨髓、扁桃体、心脏、肺、睾丸、结肠、神经元细胞、神经胶质细胞中表达[2]。IL-36 gamma 在外周血淋巴细胞、角质细胞、支气管上皮细胞和 THP-1 细胞中表达[2].

IL-36 consists of three subforms (IL-36α, IL-36β, IL-36γ), and belongs to IL-1 superfamily. IL-36 is normally expressed at low levels. Upon stimulation, they are inducted and act on a variety of cells including epithelial and immune cells. IL-36 mediates inflammatory response, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases, such as cathepsin G, elastase and proteinase-3[1].
IL-36 alpha binds to IL-36R and activates NF-κB and MAPK signaling pathways, thereby mediating inflammatory response[1]. IL-36 alpha is expressed in monocytes, T/B-lymphocytes, spleen, bone-marrow tonsils, lymph nodes and skin[2]. L-36 beta or IL-36 gamma binds to IL-36R and recruits the co-receptor IL-1RAcP, So that heterodimeric signaling complex brings Toll/IL-1R (TIR) domains of the 2 receptor chains in close proximity, and thereby activating NF-κB and MAPK signaling pathways[3]. IL-36 beta is expressed in monocytes, T/B-lymphocytes, bone-marrow, tonsils, heart, lung, testis, colon, neuron cells, glial cells[2]. IL-36 gamma is expressed in peripheral blood lymphocytes, keratinocytes, bronchial epithelial cells and THP-1 cells[2].

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