Annexin A3/ANXA3 蛋白, Human

Annexin A3 Protein, Human is a 37 kDa endogenous and secretory multifunctional protein which belongs to the annexin family. Annexin A13 is highly expressed in various carcinomas cells. Human Annexin A3 can promote aggressive cancer and stem cell-like properties and can be used as a useful predictive biomarker in HCC^[1].

膜联蛋白由一个蛋白质家族组成，参与细胞膜动力学的许多方面和膜相关蛋白的调节。
膜联蛋白 A3，也称为膜联蛋白 III 和脂皮质素 III (LPC3)，是一种钙依赖性蛋白磷脂结合蛋白优先位于质膜的胞质面上。人膜联蛋白 A3 与小鼠和大鼠膜联蛋白 A3 的氨基酸序列同一性分别为 89% 和 85%^[1][2]。

Human

E. coli

Tag Free

P12429 (M1-D323)

306  [NCBI]

MASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKICGGDD

Approximately 33.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Man Tong, et al. Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib. J Hepatol. 2018 Oct;69(4):826-839.  [Content Brief]

  [2]. Juan Wang, et al. Annexin A3 may play an important role in ochratoxin-induced malignant transformation of human gastric epithelium cells. Toxicol Lett. 2019 Oct 1;313:150-158.  [Content Brief]