2. Gene
  3. ANXA3 - annexin A3 Gene

ANXA3 - annexin A3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：膜联蛋白 A3

种属: Homo sapiens

同用名: ANX3

基因 ID: 306 | 基因类型: protein coding

关于 ANXA3

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:78,551,770-78,610,447 (from NCBI)

This gene has 10 transcripts (splice variants), 233 orthologues and 12 paralogues. Broad expression in bone marrow (RPKM 99.1), lung (RPKM 76.4) and 15 other tissues.

功能概要

该基因编码膜联蛋白家族的一个成员。这种钙依赖性磷脂结合蛋白家族的成员在调节细胞生长和信号转导通路中发挥作用。该蛋白在抑制磷脂酶 A2 和裂解肌醇 1,2-环磷酸以形成肌醇 1-磷酸方面发挥作用。这种蛋白质也可能在抗凝血中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]

ANXA3 基因产物(1)

mRNA Protein Name
NM_005139.3 NP_005130.1 annexin A3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium-dependent phospholipid binding IDA
IDA: 通过直接分析推断
2138016 GOA
enables calcium-dependent protein binding IPI
IPI: 通过物理相互作用推断
15226301 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in defense response to bacterium IDA
IDA: 通过直接分析推断
9497492 GOA
involved in neutrophil degranulation IDA
IDA: 通过直接分析推断
9550422 GOA
involved in phagocytosis IDA
IDA: 通过直接分析推断
9497492 GOA
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
16236264 GOA
involved in positive regulation of angiogenesis IDA
IDA: 通过直接分析推断
16236264 GOA
involved in positive regulation of endothelial cell migration IDA
IDA: 通过直接分析推断
16236264 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17205602 GOA
located in membrane IDA
IDA: 通过直接分析推断
17205602 GOA
located in phagocytic vesicle membrane IDA
IDA: 通过直接分析推断
7526843 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
7526843 GOA
located in specific granule IDA
IDA: 通过直接分析推断
7526843 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANXA3 蛋白结构

Annexin

Annexin: Annexin (23 - 87)

Annexin

Annexin: Annexin (94 - 159)

Annexin

Annexin: Annexin (177 - 243)

Annexin

Annexin: Annexin (255 - 317)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
蛋白主名 其他名称

annexin A3

35-alpha calcimedin

重组 ANXA3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7516 Annexin A3/ANXA3 Protein, Human P12429 (M1-D323) ≥95%

关联疾病

疾病名称 别名
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00763 ANXA3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ANXA3 MGD MGI:1201378
Felis catus ANXA3 VGNC VGNC:67699
Bos taurus ANXA3 VGNC VGNC:25965
Canis familiaris ANXA3 VGNC VGNC:37940
Rattus norvegicus ANXA3 RGD RGD:2119
Macaca mulatta ANXA3 VGNC VGNC:69948
Others ANXA3 NCBI
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