Annexin A7/ANXA7 蛋白, Human

Annexin A7 Protein, Human is a 51 kDa multifunctional protein which belongs to the the group A annexin family and contains an extraordinarily long amino terminus. Annexin A7 is a membrane binding protein with diverse properties including voltage sensitive calcium channel activity, ion selectivity and membrane fusion^[1][2].

膜联蛋白由一个蛋白质家族组成，参与细胞膜动力学的许多方面和膜相关蛋白的调节。
膜联蛋白 A7 由 ANXA7 基因编码，是第一个分离的膜联蛋白，介导 Ca ²⁺-调节嗜铬颗粒胞吐作用。膜联蛋白 7 的分子量约为 51 kDa，具有独特的、高度疏水的 N 端结构域（含 167 个氨基酸）和保守的 C 端区域（含 299 个氨基酸）。膜联蛋白 A7 在胞吐过程中的膜融合中发挥着重要作用，主要定位于细胞质中，并且在大脑、心脏和骨骼肌中表现出较高的患病率^[1]。

Human

E. coli

Tag Free

P20073-2 (M1-Q488)

310  [NCBI]

MSYPGYPPTGYPPFPGYPPAGQESSFPPSGQYPYPSGFPPMGGGAYPQVPSSGYPGAGGYPAPGGYPAPGGYPGAPQPGGAPSYPGVPPGQGFGVPPGGAGFSGYPQPPSQSYGGGPAQVPLPGGFPGGQMPSQYPGGQPTYPSQPATVTQVTQGTIRPAANFDAIRDAEILRKAMKGFGTDEQAIVDVVANRSNDQRQKIKAAFKTSYGKDLIKDLKSELSGNMEELILALFMPPTYYDAWSLRKAMQGAGTQERVLIEILCTRTNQEIREIVRCYQSEFGRDLEKDIRSDTSGHFERLLVSMCQGNRDENQSINHQMAQEDAQRLYQAGEGRLGTDESCFNMILATRSFPQLRATMEAYSRMANRDLLSSVSREFSGYVESGLKTILQCALNRPAFFAERLYYAMKGAGTDDSTLVRIVVTRSEIDLVQIKQMFAQMYQKTLGTMIAGDTSGDYRRLLLAIVGQ

Approximately 47.0 kDa

Greater than 80% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Weihua Ye, et al. Effect of annexin A7 suppression on the apoptosis of gastric cancer cells. Mol Cell Biochem. 2017 May;429(1-2):33-43.  [Content Brief]

  [2]. Hu-Fang Yuan, et al. Downregulation of annexin A7 decreases proliferation, migration, and invasion of gastric cancer cells by reducing matrix metalloproteinase 1 and 9 expression. Am J Transl Res. 2019 May 15;11(5):2754-2764.  [Content Brief]