ANXA7 - annexin A7 Gene

中文名称：膜联蛋白 A7

种属: Homo sapiens

同用名: SNX; ANX7; SYNEXIN

关于 ANXA7

功能概要

膜联蛋白 VII 是钙依赖性磷脂结合蛋白膜联蛋白家族的一员。膜联蛋白 VII 基因包含 14 个外显子，跨越约 34 kb 的 DNA。选择性剪接的盒式外显子产生两个 2.0 和 2.4 kb 的 mRNA 转录本，预计它们会产生两个 N 末端结构域不同的蛋白质亚型。可变剪接事件是组织特异性的，含有盒式外显子的 mRNA 在大脑、心脏和骨骼肌中普遍存在。通过使用两个替代的 poly (A) 信号，转录本的 3'-非编码区也不同。 Annexin VII 编码一种分子量约为 51 kDa 的蛋白质，具有独特的高度疏水性 N 末端结构域 (167 个氨基酸) 和保守的 C 末端区域 (299 个氨基酸) 。后一结构域由交替的疏水和亲水部分组成。蛋白质的结构分析表明，膜联蛋白 VII 是一种具有多种特性的膜结合蛋白，包括电压敏感钙通道活性、离子选择性和膜融合。[RefSeq 提供，2008 年 7 月]

Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 Amino acids and a conserved C-terminal region of 299 Amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive Calcium Channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]