APCDD1 蛋白, Human (466a.a, HEK293, Fc)

APCDD1 protein, a homodimer, negatively regulates the Wnt signaling pathway, acting cell-autonomously upstream of beta-catenin. Implicated in colorectal tumorigenesis, it interacts with LRP5 and WNT3A, suggesting involvement in complex interactions with Wnt and LRP proteins. APCDD1's pivotal role is evident in its contribution to intricate regulatory mechanisms governing Wnt signaling. APCDD1 Protein, Human (466a.a, HEK293, Fc) is the recombinant human-derived APCDD1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of APCDD1 Protein, Human (466a.a, HEK293, Fc) is 466 a.a., with molecular weight of 82-110 kDa.

APCDD1 蛋白在 Wnt 信号通路中充当负调节因子，以细胞自主方式发挥其抑制作用，并在 β-连环蛋白的上游发挥作用。它在结直肠肿瘤发生中的潜在作用表明它在与这种情况相关的细胞过程中的重要性。作为同二聚体，APCDD1 与 LRP5 和 WNT3A 相互作用，表明它参与与 Wnt 和 LRP 蛋白的复杂相互作用。这些相互作用共同构成了控制 Wnt 信号传导的复杂调节机制，凸显了 APCDD1 在调节该通路中的关键作用。

Immobilized Human APCDD1, hFc Tag at 2 μg/mL (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-APCDD1 Antibody, hFc Tag with the EC₅₀ of 17.8 ng/mL determined by ELISA.

Human

HEK293

C-hFc

Q8J025 (L27-H492)

147495

LLHPDSRSHPRSLEKSAWRAFKESQCHHMLKHLHNGARITVQMPPTIEGHWVSTGCEVRSGPEFITRSYRFYHNNTFKAYQFYYGSNRCTNPTYTLIIRGKIRLRQASWIIRGGTEADYQLHNVQVICHTEAVAEKLGQQVNRTCPGFLADGGPWVQDVAYDLWREENGCECTKAVNFAMHELQLIRVEKQYLHHNLDHLVEELFLGDIHTDATQRMFYRPSSYQPPLQNAKNHDHACIACRIIYRSDEHHPPILPPKADLTIGLHGEWVSQRCEVRPEVLFLTRHFIFHDNNNTWEGHYYHYSDPVCKHPTFSIYARGRYSRGVLSSRVMGGTEFVFKVNHMKVTPMDAATASLLNVFNGNECGAEGSWQVGIQQDVTHTNGCVALGIKLPHTEYEIFKMEQDARGRYLLFNGQRPSDGSSPDRPEKRATSYQMPLVQCASSSPRAEDLAEDSGSSLYGRAPGRH

82-110 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.