APLP-1 蛋白, Mouse (HEK293, His)

APLP-1 protein is involved in postsynaptic function and synaptic processes. Its processing produces ALID1, which activates transcription through APBB1 binding. APLP-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived APLP-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of APLP-1 Protein, Mouse (HEK293, His) is 584 a.a., with molecular weight of 70-95 kDa.

APLP-1 蛋白可能在突触后功能中发挥作用，表明它参与了突触位点发生的复杂过程。由 γ 分泌酶加工产生的 C 端片段 ALID1，表现出通过与 APBB1 (Fe65) 结合激活转录的能力。APLP-1 还通过与 C 末端区域相互作用参与 JIP 信号转导。此外，它似乎与细胞 G 蛋白信号传导途径有关，表明其对多种细胞信号传导机制的潜在影响。此外，APLP-1 可以通过与肝素和 I 型胶原蛋白等细胞外基质成分结合来调节神经突生长。然而，源自 APLP-1 的 γ-CTF 肽 C30 因其有效增强神经元凋亡而值得注意，这强调了APLP-1 在细胞过程中的功能作用的双重性质。进一步探索这些不同作用背后的具体机制可以为 APLP-1 在神经发育和稳态中的多方面功能提供有价值的见解。

Mouse

HEK293

C-10*His

Q03157 (N39-E584)

11803  [NCBI]

NLAVGSPSAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLLDPQRVLEYCRQMYPELHIARVEQAAQAIPMERWCGGTRSGRCAHPHHEVVPFHCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPATPNPSGMAAGDPSTRSWPLGGRAEGGEDEEEVESFPQPVDDYFVEPPQAEEEEEEEEERAPPPSSHTPVMVSRVTPTPRPTDGVDVYFGMPGEIGEHEGFLRAKMDLEERRMRQINEVMREWAMADSQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQGDPPQAERVLMALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVQTHLQVIEERMNQSLGLLDQNPHLAQELRPQIQELLLAEHLGPSELDASVPGSSSEDKGSLQPPESKDDPPVTLPKGSTDQESSSSGREKLTPLEQYEQKVNASAPRGFPFHSSDIQRDELAPSGTGVSREG

Approximately 70-95 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.